Caspase 9

A long pro-domain caspase that contains a CASPASE RECRUITMENT DOMAIN in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.

Also Known As:

Apoptotic Protease Activating Factor 3; Caspase-9; ICE-LAP6 Protein; ICE-Like Apoptotic Protease 6; Pro-Caspase-9; Procaspase-9; ICE LAP6 Protein; ICE Like Apoptotic Protease 6; Pro Caspase 9; Procaspase 9

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Cysteine Proteases: 1994
        Cysteine Endopeptidases: 4
        Caspases: 9499
        Initiator Caspases: 34
        Caspase 9: 2373
      - Endopeptidases: 643
        Cysteine Endopeptidases: 4
        Caspases: 9499
        Initiator Caspases: 34
        Caspase 9: 2373
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Caspase 9: 2373
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2581
      - Caspases: 9499
        Initiator Caspases: 34
        Caspase 9: 2373
      - CARD Signaling Adaptor Proteins
        Caspase 9: 2373
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Caspase 9: 2373

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Disease

Drug/Important Bio-Agent (IBA)